Sunday, August 23, 2009

Evidence for...Folic acid for heart disease prevention

Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease.
Yilmaz H et al.
Acta Cardiol. 2007;62:579-85.
In patients with hyperhomocysteinaemic coronary artery disease, folic acid 5 mg/day for 8 weeks lowered plasma homocysteine levels and improved endothelial function.


Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
Shirodaria C et al.
Circulation. 2007;115:2262-70.
In patients scheduled to undergo coronary artery bypass grafting, 7 weeks' treatment with low-dose folic acid treatment (400 microg/day), comparable to daily intake and dietary fortification, improved vascular function through effects on endothelial nitric oxide synthase and vascular oxidative stress. High-dose folic acid treatment (5 mg/day) provided no additional benefit.


Dietary intake of folate equivalents and risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition (EPIC)--Potsdam study.
Drogan D et al.
Public Health Nutr. 2006;9:465-71.
In this large German study population (22,245 apparently healthy non-users of vitamin supplements aged 35-64 years), higher intake of dietary folate equivalents was associated with decreased risk of myocardial infarction.

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