A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids.
Lin PY and Su KP.
J Clin Psychiatry. 2007;68:1056-61.
This meta-analysis systematically evaluated the therapeutic benefit of omega-3 polyunsaturated fatty acids (PUFAs) using data from 10 double-blind, placebo-controlled studies in patients with mood disorders receiving omega-3 PUFAs for ≥4 weeks. Omega-3 PUFAs showed significant antidepressant efficacy, with significant improvement of depression in patients with clearly defined depression or with bipolar disorder.
Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique.
Sontrop J & Campbell MK.
Prev Med. 2006;42(1):4-13.
In this review, depression was significantly improved in 4 of 7 double-blind randomised controlled trials that involved treatment with ≥1 g/day of eicosapentaenoic acid (an omega-3 polyunsaturated fatty acid).
In this review, depression was significantly improved in 4 of 7 double-blind randomised controlled trials that involved treatment with ≥1 g/day of eicosapentaenoic acid (an omega-3 polyunsaturated fatty acid).
Omega-3 treatment of childhood depression: a controlled, double-blind pilot study.
Nemets H et al.
Am J Psychiatry. 2006;163:1098-100.
The efficacy of omega-3 fatty acids were examined in 28 children (aged 6-12 years) with major depressive disorder, who received omega-3 fatty acids or placebo as pharmacological monotherapy, for 16 weeks. Analyses showed highly significant effects of omega-3 on symptoms using the Children's Depression Rating Scale, Children's Depression Inventory, and Clinical Global Impression.
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