Improvement of diabetic microangiopathy with pycnogenol: A prospective,
controlled study.
Cesarone MR et al.
Angiology. 2006;57:431-6.
30 patients with severe diabetic microangiopathy received oral pycnogenol (50 mg capsules, 3 times daily for a total of 150 mg/day) for 4 weeks. After 4 weeks, microangiopathy levels had improved, capillary filtration had significantly decreased, and the venoarteriolar response had significantly improved. Treatment was well tolerated.
Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol.
Belcaro G et al.
Clin Appl Thromb Hemost. 2006;12:318-23.
In diabetic patients with severe microangiopathy causing leg ulcerations, 6 weeks' combined oral and local pycnogenol treatment completely healed 89% of patients and improved microcirculation. No side effects were reported.
Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II.
Liu X et al.
Life Sci. 2004;75:2505-13.
Supplementation with pycnogenol 100 mg for 12 weeks, in addition to conventional antidiabetic treatment, significantly lowered plasma glucose levels as compared to placebo, in patients with type 2 diabetes mellitus.
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