Grapefruit juice may boost CoQ10 uptake:

Grapefruit juice may boost CoQ10 uptake: Study: "A glass of grapefruit juice may improve intestinal absorption of coenzyme Q10 (CoQ10) by almost 50 per cent, says a new study from Japan.

The juice appears to inhibit a protein in the membrane of cells called P-glycoprotein (P-gp), which thereby leads to an increased absorption of CoQ10, according to results of a laboratory study published in Food Chemistry.

“We have demonstrated that a higher cellular uptake of CoQ10 was achieved in the presence of grapefruit juice,” wrote the Japanese researchers, led by Ken Iseki from Hokkaido University.

The formulation of the CoQ10 is known to play a key role in its bioavailability. Since the coenzyme is lipophilic (fat-loving) its absorption is enhanced in the presence of lipids. Therefore, when taken as a supplement apart from meals, the absorption of some formulations is lower.

“It is possible that co-administration of CoQ10 with grapefruit juice constitutes an easily accessible way to improve the intestinal absorption of CoQ10,” added Iseki and his co-workers."